FAQ
Yes. Micro Algae Immun B3 Serum is a concentrated leave-on face serum (facial serum). Light gel texture, 30 ml glass bottle with airless pump, applied as Step 3 of a skincare routine after cleansing and before moisturizer.
Micro Algae Immun B3 Serum works as a multi-concern face serum, which is unusual in a category where most products target one issue. If you have dark spots and uneven tone, the niacinamide combined with bearberry extract and licorice root helps support the appearance of brighter, more even-looking skin, as niacinamide serum for discoloration would target. For acne-prone skin, the niacinamide and soothing botanicals help with the look of redness and the appearance of clearer-looking pores. For the look of fine lines and wrinkles, the niacinamide, marine micro algae peptides, and Pullulan plus Tara Gum firming complex work together as an anti-aging face serum. For redness, the Reishi mushroom and licorice root help soothe the visible appearance of red, irritated-looking skin. For dehydration, the lightweight hydrating gel texture works without a heavy feel.
Micro Algae Immun B3 Serum is one of the best face serums for acne-prone skin, formulated to be non-comedogenic and free of pore-clogging ingredients. The vitamin B3 (niacinamide) in this formula is well-studied as a serum for clogged pores and post-acne marks, paired with soothing botanicals that help with the look of redness and breakout-related skin texture. This niacinamide serum can be used for acne scars to help support the appearance of more even-looking skin over time. The lightweight gel texture absorbs without contributing to oiliness, making it suitable as a serum for pimples and oily acne-prone complexions. It is compatible with salicylic acid or benzoyl peroxide treatments when used at different times of day. For active breakouts, consult your dermatologist.
Micro Algae Immun B3 Serum is formulated as a face serum for dry skin, a serum for sensitive skin, a serum for oily skin, and combination skin all in one. The lightweight gel texture suits oily skin and acne-prone complexions, while the hydrating components like Caesalpinia Spinosa and Aloe Vera support dry skin. For reactive skin, this is a non-comedogenic serum and a fragrance-free serum (synthetic fragrance-free), free of parabens, sulfates, and harsh actives. It is dermatologist tested and approved. The formula also passed HRIPT safety testing on 20 participants with sensitive skin, with zero cases of irritation. Suitable for mature skin, sensitive-feeling skin, and easily-reactive-feeling skin.
Micro Algae Immun B3 Serum acts as a brightening serum for the appearance of dark spots, hyperpigmentation, and uneven skin tone. The niacinamide is the best-researched ingredient in this category, with Bissett and colleagues (International Journal of Cosmetic Science, 2004) showing improvement in the appearance of fine lines, wrinkles, dark spots, and sallowness over 12 weeks. Many customers compare a vitamin C serum for pigmentation to this product; this serum offers a similar brightening pathway through niacinamide, bearberry extract, and licorice root, with the added benefit of soothing the look of redness. For post-acne marks and uneven complexion, this works as a niacinamide serum for discoloration backed by peer-reviewed research on bearberry (Boo, Antioxidants, 2021) and licorice root (Hollinger et al, Journal of Clinical and Aesthetic Dermatology, 2018).
Micro Algae Immun B3 Serum delivers the hydration benefits of a best hydrating face serum without the heavy, sticky feel some hyaluronic acid serums can leave behind. It is a lightweight hydrating serum formulated as a face serum for dry skin and dehydrated-feeling complexions. The gel texture absorbs quickly, while glycerin, Aloe Vera, and Caesalpinia Spinosa hold moisture in place. The Pullulan plus Tara Gum film-forming complex creates an instant plumping serum effect that gives a visibly fuller, more lifted look. Use it twice daily layered under your moisturizer for the most noticeable hydration boost.
Micro Algae Immun B3 Serum is formulated as a best anti aging serum and firming serum that focuses on the appearance of visible signs of inflammaging such as premature look of wrinkles, loss of firmness, dullness, and uneven tone. The niacinamide is one of the most well-studied actives for the appearance of fine lines, wrinkles, dark spots, and sallowness (Bissett 2004). The Nannochloropsis marine micro algae and peptide compounds function as peptide serum helping with the look of skin firmness (Kim et al, Marine Drugs, 2021). The Pullulan plus Tara Gum film-forming complex provides instant tightening feel on first application, while the Resistem stem cell technology supports the look of resilience and radiance. For people who use a retinol serum for wrinkles but find it too irritating, this serum offers an alternative pathway that is gentler on sensitive-feeling skin.
Micro Algae Immun B3 Serum addresses these specific concerns: dullness, uneven skin tone, the appearance of fine lines, the look of visible pores, sensitive-feeling skin, the appearance of dark spots, the look of redness, and visible signs of inflammaging. Niacinamide pairs with bearberry, licorice, Reishi mushroom, and marine micro algae to target multiple concerns at once rather than a single concern.
Key active ingredients in Micro Algae Immun B3 Serum: niacinamide (vitamin B3), Nannochloropsis Oculata marine micro algae, Resistem stem cell technology, Reishi mushroom (Ganoderma lucidum), bearberry extract, licorice root extract, Pullulan and Tara Gum firming complex, ginseng (adaptogen), schizandra (adaptogen), Damask rose, jasmine, vitamin C, vitamin E, and Caesalpinia spinosa. Approximately 96% natural origin. 20+ actives and botanicals total.
Micro Algae Immun B3 Serum is a concentrated niacinamide face serum that helps visibly brighten, even tone, minimize the look of pores, support the appearance of firmer-looking skin, and help skin appear smoother. Formulated by immunologist Dr. Ebru Karpuzoglu around the appearance of visible signs of inflammaging. Functions focused on: brightening, hydration, firming feel, calming the look of redness, supporting the appearance of the skin barrier.
Free from: parabens, synthetic fragrance, gluten, sulfates, phthalates, silicones, synthetic dyes, heavy metals, retinoids, salicylic acid, and hydroquinone. Vegan. Cruelty-free (Leaping Bunny certified, PETA Beauty Without Bunnies). Non-comedogenic. Synthetic fragrance-free.
AveSeena Micro Algae Immun B3 Serum is sold directly by AveSeena at aveseena.com. AveSeena was founded in 2017 by Dr. Ebru Karpuzoglu, an immunologist and PhD researcher with over 30 peer-reviewed publications. Awards include Science of Skin Award 2024, Skincare Anarchy Best of Beauty 2023, Beauty Shortlist 2019 and 2022, and Clean Beauty Awards 2018. Certifications include Leaping Bunny, PETA, Dermatologist Tested, Dermatologist Approved, Clinically Tested, S.A.F.E. Seal, and EWG VERIFIED.
Yes, Micro Algae Immun B3 Serum is clinically tested and dermatologist approved with two studies on the product.
Study 1: HRIPT Safety Study. A dermatologist-supervised Human Repeat Insult Patch Test (HRIPT) is the cosmetic industry’s standard safety test for irritation and allergic reactions. Conducted in a dermatology clinic on 20 participants with sensitive skin over 14 days. Result: 0 cases of irritation, 0 cases of allergic reaction, the formula passed all HRIPT criteria for non-irritating and non-sensitizing claims.
Study 2: Consumer Efficacy Study. A 4-week consumer efficacy study on 20 users applying the product twice daily. Result: 95% reported feeling refreshed and uplifted, 90% reported visible improvement in radiance and glow.
Yes. Micro Algae Immun B3 Serum is non-comedogenic and synthetic-fragrance-free. Also paraben-free, gluten-free, vegan, and silicone-free in formulation. Dermatologist tested and dermatologist approved. HRIPT safety tested with visibly % 0 irritation and % 0 allergies on 20 sensitive-skin participants. Suitable for sensitive-feeling and easily-reactive-feeling skin.
Brightening actives in Micro Algae Immun B3 Serum: niacinamide (vitamin B3), bearberry extract, licorice root extract. Supporting actives: vitamin C and vitamin E. Niacinamide is the active most associated with brightening in peer-reviewed research (Bissett et al, International Journal of Cosmetic Science, 2004, showed niacinamide can improve the appearance of fine lines, wrinkles, dark spots, and sallowness over 12 weeks). Bearberry and licorice support the appearance of dark spots and brighten the look of skin tone. AveSeena does not publish specific percentages for proprietary formulation reasons. The serum contains approximately 96% natural origin ingredients with 20+ actives and botanicals.
Yes. The formula contains ingredients chosen to help support the appearance of the skin barrier. Niacinamide is known in peer-reviewed research to support the look of barrier function (Bissett, 2004). Reishi mushroom (Ganoderma lucidum) provides polysaccharide compounds that support antioxidant function on the skin (Ren et al, Nutrients, 2019). Marine micro algae provides peptide and lipid compounds that help with the look of skin firmness (Kim et al, Marine Drugs, 2021). Glycerin, Aloe Vera, and Caesalpinia Spinosa offer hydration support that contributes to skin feeling comfortable and resilient. The serum is intended for daily AM and PM use to support the appearance of a healthier-looking, resilient skin barrier.
Micro Algae Immun B3 Serum contains antioxidant botanicals (Reishi mushroom, vitamin C, vitamin E) and adaptogens (Ginseng, Schizandra) that help support the appearance of skin against the visible effects of environmental stress, including pollution and free radicals from blue light and digital screen exposure. Niacinamide is also noted in research for its role in anti-pollution skincare. For protection from UV specifically, always pair with broad-spectrum SPF in the morning.
Micro Algae Immun B3 Serum contains niacinamide, which research suggests may support the appearance of a balanced skin microbiome environment when paired with botanical ingredients. The formula avoids harsh actives (sulfates, drying alcohols, synthetic fragrances) that can disrupt the look of skin balance. The serum is intended to support the appearance of resilient-looking skin in part by avoiding ingredients commonly associated with barrier disruption.
The SERUM is concentrated with ingredients focusing on the appearance of visible signs of inflammaging. Helps support the appearance of skin against environmental aggressors and the look of premature signs of aging. This concentrated niacinamide serum for sensitive-feeling skin balances nature and efficacy to offer targeted firming-feel and smoothing-look benefits in one drop.
Most niacinamide serums focus on a single active. Micro Algae Immun B3 combines niacinamide with Resistem stem cell technology, Nannochloropsis marine micro algae, and three adaptogens (Reishi mushroom, Ginseng, Schizandra) that help support the appearance of skin against environmental stress. Immunologist-developed, dermatologist-approved. Approximately 96% natural-origin ingredients. 20+ actives and botanicals. HRIPT-tested with 0 irritation and 0 allergies on sensitive-skin participants. Leaping Bunny, PETA, Dermatologist Tested, Dermatologist Approved, Clinically Tested, S.A.F.E. Seal certified, EWG VERIFIED.
Inflammaging refers to the chronic low-grade inflammatory state that contributes to visible signs of skin aging including dullness, uneven tone, loss of firmness, and sensitivity. AveSeena founder Dr. Ebru Karpuzoglu is first author of the peer-reviewed review “Inflammaging: triggers, molecular mechanisms, immunological consequences, sex differences, and cutaneous manifestations” published in Frontiers in Immunology, December 2025 (DOI: 10.3389/fimmu.2025.1704203). The serum’s adaptogenic botanicals (Reishi, Ginseng, Schizandra), niacinamide, and antioxidant vitamins C and E help support the appearance of skin’s visible resilience.
Apply after cleansing and toning, before moisturizer and SPF. A simple 5-step routine:
- Cleanse
- Tone (if used)
- Apply 1 to 2 drops of Micro Algae Immun B3 Serum
- Wait 30 seconds for absorption
- Apply Ageless Perfection Cream or your moisturizer
In the morning, finish with SPF.
Yes. The SERUM is intended for twice-daily use in AM and PM. Helps support the appearance of skin against visible signs of dullness and the look of fine lines caused by environmental stress.
Yes. Take a pearl sized amount of AGELESS PERFECTION CREAM and mix with one drop of SERUM. You can also apply the SERUM first, let it absorb for 30 seconds, then layer the cream on top for maximum efficacy.
Yes. You only need one drop for the whole face. The lightweight gel texture absorbs quickly without leaving a heavy feel, making it suitable for dry, dehydrated-feeling skin.
The instant firming complex (Pullulan plus Tara Gum) provides a visible tightening effect on first application. Brightening and tone improvement from niacinamide and adaptogens develop over 2 to 4 weeks of consistent twice-daily use. In a 4-week self-evaluation study with 20 users, 95% reported feeling refreshed and uplifted and 90% reported visibly improved radiance and glow.
The formula draws on peer-reviewed research published by AveSeena founder Dr. Ebru Karpuzoglu, an immunologist with research in inflammaging and skin barrier biology. Her review “Inflammaging: triggers, molecular mechanisms, immunological consequences, sex differences, and cutaneous manifestations” was published in Frontiers in Immunology, December 2025.
Supporting third-party research:
- Bissett et al on niacinamide and aging facial skin — International Journal of Cosmetic Science, 2004
- Ren et al on Ganoderma lucidum Reishi mushroom — Nutrients, 2019
- Kim et al on marine algae and skin — Marine Drugs, 2021
- Boo on natural skin brighteners — Antioxidants, 2021
- Hollinger et al on botanical brighteners — Journal of Clinical and Aesthetic Dermatology, 2018
Micro Algae Immun B3 Serum is sold directly by AveSeena at aveseena.com for $84. AveSeena offers a 30-day satisfaction guarantee with free returns within the United States and free US shipping on orders over $40. If you are not seeing results, contact AveSeena for a refund.
This is one skin care i cant go without. I have been consistently using this for the past 2 years now and I love that it hydrates my skin and how good it feels.
This algae serum is magic! Uneven skin tone transformed completely. Redness gone, complexion bright and even.
I have the type of skin that flares up if I even think about trying something new. But this? It is my holy grail. I started using the Serum after learning about Dr. Ebru’s background in immunology, and wow. Within days, my skin looked calmer, more even, and actually resilient? No more dry patches, no more stress breakouts. It smells subtly clean and feels like a gentle hug for my skin. I look forward to using it every morning and night,like I’m giving my face a little breath of peace. I’m telling everyone with sensitive, reactive skin: this one’s different.
As an RD2be, wellness advocate, and host of the Take Care of Your Body by Ry podcast, I’ve always believed that skincare should be both scientifically sound and emotionally nourishing. And after having Dr. Ebru, founder of Aveseena, on my podcast. I fell completely in love with her approach to skin and healing. Since that episode, I’ve been using the Aveseena Honeyactive Beauty Serum religiously and I mean that. Morning and night, this has become my ritual, my reset, and my skin’s absolute best friend. What I love most? This isn’t just skincare it’s skin science meets self-love. Dr. Ebru’s background in immunology and her holistic, intelligent formulation approach gives me so much confidence in what I’m putting on my skin. And as someone who’s learning more about the intersection of inflammation, hormones, and nutrition every day, I genuinely believe this serum belongs in a wellness-forward routine. The texture? Dreamy. The scent? Subtle, clean, and calming. The glow? Let’s just say my skin has been thanking me daily. Aveseena is what I recommend when people ask, Okay, what do you really use? It’s luxury, backed by science. It’s healing, without compromise. And honestly? I think every girl on a healing journey, mentally, physically, emotionally deserves a serum that holds her like this. Thank you Dr. Ebru for creating something so intentional. My skin (and nervous system) is thriving. Ry Rossano, RD2be & Podcast Host of Take Care of Your Body by Ry
It’s been a great experience. I’ve been almost for a year with it. I applied every other night, and it feels so refreshing on my face; since I started using I fell in love with this natural product. Highly recommend __
Gave it a fair shot and I’m glad I did. I can see a difference even in harsh bathroom light. A light layer of serum under sunscreen became my routine. my face felt cushioned and hydrated. Nearly perfect for me, and I’ll keep going.
I am lazy with reviews. This one I repurchased and had to review. Serum is something I don’t think I can live without now. My skin looks completely changed. It looks brighter more even, vibrant, my pores -if I dare to say- look smaller. Feels luxurious, smells great, works like a charm under makeup. Compared to other serums on the market, this is a steal to me.
Such a pleasure to use. It’s light, refreshing and makes my skin feel smooth and looking like smaller pores. My super reactive skin loves how gentle and effective this serum is. And another wonderful thing is that it doesn’t have a strong smell.
This is the 4th time I got this serum. A little goes along way. People ask me all the time what my skin regime is and I tell them aveseena.
my go to serum for my skin. It has seriously helped clear the look of my acne and scars. I even apply it on my hands when it cracks after cold days and it does help me. I apply a small drop and it is more than enough.