nobody is immune to sensitive skin

Sensitive skin is a widespread condition, often manifesting as redness, irritation, itchiness, or dryness in response to environmental or product triggers (1). Although some individuals might be more susceptible due to a hyperactive immune system, sensitive skin can affect anyone at any time. Inflammaging, a term describing chronic, low-grade inflammation associated with aging, may worsen sensitive skin conditions (2).

Various factors, such as environmental elements, topical acidic products, stress, lack of sleep, or hormonal fluctuations, can trigger skin irritation. Sensitivities can lead to weakened skin barrier functions and more severe inflammatory conditions like eczema, rosacea, psoriasis, or acne (3).

People with sensitive skin may have dry, oily, or combination skin types, and realistically, nobody is “immune” to sensitive skin.

Exploring Sensitive Skin Causes and Inflammaging Links

1- The Genetic Connection: Specific gene variants may predispose individuals to sensitive skin or inflammaging, leading to increased inflammation (4, 5).

2- Environmental Impact: Harsh weather conditions, pollution, and UV radiation exposure can trigger inflammation and irritation, contributing to inflammaging (6, 7).

3- Hormonal Shifts: Hormonal fluctuations, particularly during menopause or andropause, can cause skin changes, increasing sensitivity and inflammation (8).

4- Skincare Product Culprits: Skincare products with harsh chemicals, acids, or fragrances may irritate and inflame the skin, exacerbating inflammaging (9-12).

5- Medical Conditions: Certain conditions like eczema, rosacea, and psoriasis can increase skin sensitivity and contribute to inflammaging (12-13).

``None of us is ``immune`` to sensitive skin. Sensitivity touches us all - be kind to yours.``

- Dr. Ebru

Combating Signs of Inflammaging with Sensitive Skin-Friendly Skincare Products


To mitigate inflammaging for sensitive skin, opt for non-irritating, gentle, and specially formulated skincare products. Here are some product categories and AveSeena options ideal for sensitive skin:

1- Gentle Cleansers for Sensitive Skin: Choose cleansers free from harsh chemicals and fragrances, containing gentle, plant-based ingredients (14). Our Gentle Gardenia Anti-Pollution Gel Cleanser offer a soothing cleanse followed with lukewarm water recommended for minimal irritation (15).

2- Hydrating Moisturizers for Calm Skin: Fragrance-free moisturizers like AveSeena’s range for sensitive skin keep the skin visibly hydrated and reduce inflammation. Hydrating and soothing ingredients such as hyaluronic acid, glycerin, and aloe vera are important in supporting sensitive skin (16, 17).

3- Sensitive Skin-Friendly Sunscreen: Sunscreen with at least SPF 30 protects against inflammation-causing UV radiation (18). Pick sunscreens free from harsh chemicals and with mineral-based active ingredients like zinc oxide or titanium dioxide (19).

4- Soothing Face Oils: Green Caviar Facial Oil Elixir with gentle ingredients like jojoba, squalene, and vitamin E help reduce signs of inflammation and support skin barrier function (20, 21).

5- Antioxidant-Rich Serums: Antioxidant serums, such as AveSeena’s vitamin C, vitamin E, and green tea-infused options, reduce signs of inflammaging and protect the skin from oxidative damage linked to inflammation (22, 23).

6- Skin Barrier Repair Creams: AveSeena’s skin barrier repair cream – Ageless Perfection Cream, formulated with ceramides, fatty acids, and other lipids, help strengthen the skin barrier, making it less vulnerable to irritants and reducing the visible impact of inflammaging (24).


Sensitive Skin Spares Noone: Unlocking the Secrets to Managing Sensitive Skin

In conclusion, sensitive skin is a widespread and intricate concern that impacts people at different stages of their lives. Factors like genetics, environmental conditions, hormonal shifts, skincare products, and medical issues all play a role in the development of sensitive skin. However, the key to managing and treating this condition lies in adopting a personalized and holistic approach. It’s crucial to set achievable expectations and recognize that each individual’s skin is unique, and not all treatments may yield the desired results.

To effectively tackle sensitive skin, it’s essential to pinpoint and steer clear of triggers, opt for gentle, non-irritating skincare products, and maintain a consistent skincare regimen that bolsters the skin’s barrier function. Vital product categories, including cleansers, moisturizers, sunscreens, face oils, antioxidant serums, and skin barrier repair creams, offer targeted solutions for those struggling with sensitive skin. Additionally, seeking professional advice from a dermatologist is highly recommended to ensure the most suitable and efficient treatment plan.

By establishing practical expectations and embracing a customized approach to anti-inflammatory skincare, individuals with sensitive skin can diminish the appearance of inflammation, preserve a robust skin barrier, and mitigate signs of inflammaging, ultimately enhancing their skin’s overall health and wellness.


sensitive skin

Scientific References:

  1. Misery, L., et al. (2010). Definition of sensitive skin: an expert position paper from the special interest group on sensitive skin of the International Forum for the Study of Itch. Acta Dermato-Venereologica, 90(2), 147-152.
  2. Franceschi, C., et al. (2007). Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mechanisms of Ageing and Development, 128(1), 92-105.
  3. Berardesca, E., et al. (2009). Sensitive skin: an overview. International Journal of Cosmetic Science, 31(1), 1-8.
  4. Donlon, T. A., et al. (2017). FOXO3 longevity interactome on chromosome 6. Aging Cell, 16(5), 1016-1025.
  5. Liguori, I., et al. (2018). Oxidative stress, aging, and diseases. Clinical Interventions in Aging, 13, 757-772.
  6. Krutmann, J., et al. (2014). Pollution and skin: from epidemiological and mechanistic studies to clinical implications. Journal of Dermatological Science, 76(3), 163-168.
  7. Rinnerthaler, M., et al. (2015). Oxidative stress in aging human skin. Biomolecules, 5(2), 545-589.
  8. Farage, M. A., et al. (2009). Physiological changes associated with the menstrual cycle: a review. Obstetrical & Gynecological Survey, 64(1)
  9. Draelos, Z. D. (2011). Sensitive skin: perceptions, evaluation, and treatment. American Journal of Contact Dermatitis, 12(2), 67-73.
  10. Slominski, A. T., Zmijewski, M. A., & Skobowiat, C. (2018). The role of melanin pigment in melanoma. Experimental Dermatology, 27(6), 591-595.
  11. Katta, R., & Desai, S. P. (2014). Diet and dermatology: the role of dietary intervention in skin disease. Journal of Clinical and Aesthetic Dermatology, 7(7), 46-51.
  12. Boehncke, W. H., & Schön, M. P. (2015). Psoriasis. The Lancet, 386(9997), 983-994.
  13. Two, A. M., et al. (2014). The cutaneous microbiome and aspects of skin antimicrobial defense system resist acute treatment with topical skin cleansers. Journal of Investigative Dermatology, 134(10), 2486-2494.
  14. Draelos, Z. D. (2011). Sensitive skin: perceptions, evaluation, and treatment. American Journal of Contact Dermatitis, 12(2), 67-73.
  15. Farage, M. A., et al. (2008). Intrinsic and extrinsic factors in skin ageing: a review. International Journal of Cosmetic Science, 30(2), 87-95.
  16. Papakonstantinou, E., et al. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-Endocrinology, 4(3), 253-258.
  17. Hekmatpou, D., et al. (2019). The effect of aloe vera clinical trials on prevention and healing of skin wound: A systematic review. Iranian Journal of Medical Sciences, 44(1), 1-9.
  18. Rittié, L., & Fisher, G. J. (2015). UV-light-induced signal cascades and skin aging. Ageing Research Reviews, 24, 291-303.
  19. Lin, T. K., et al. (2018). Anti-inflammatory and skin barrier repair effects of topical application of some plant oils. International Journal of Molecular Sciences, 19(1), 70.
  20. Pilkington, S. M., et al. (2018). The effects of exercise on skin health: A review of human and animal studies. Journal of Dermatological Science, 90(1), 1-8.
  21. Schagen, S. K. (2017). Topical peptide treatments with effective anti-aging results. Cosmetics, 4(2), 16.
  22. Al-Niaimi, F., & Chiang, N. Y. Z. (2017). Topical Vitamin C and the Skin: Mechanisms of Action and Clinical Applications. The Journal of Clinical and Aesthetic Dermatology, 10(7), 14-17.
  23. Katiyar, S. K. (2011). Green Tea and Skin Cancer: Photoimmunology, Angiogenesis and DNA Repair. Journal of Nutritional Biochemistry, 18(5), 287-296.
  24. Elias, P. M. (2007). The skin barrier as an innate immune element. Seminars in Immunopathology, 29(1), 3-14.



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